MRCRO

Nephrology in Pakistan & the contributions of Metrics Research in associated research initiatives

Frequently Asked Questions (FAQs)

Q1. How prevalent are renal diseases in Pakistan?

The prevalence ranges from 12.5% to 29.9% for CKD among Pakistani adults, with a prevalence of 43.6% in patients over 50 years old, which shows a significant presence of CKD in Pakistan, with higher prevalence rates compared to other South Asia regions [1].

Q2. What are the leading factors contributing to Chronic Kidney Disease (CKD) in the Pakistani population?

Diabetes and hypertension are leading contributors to chronic kidney disease (CKD) in the Pakistani population, as an estimated 33.3 million people in the country have diabetes, which translates to a staggering 26.7% of the adult population [2]. Moreover, the prevalence of hypertension in Pakistan is also high which translates to millions of Pakistanis at risk of developing CKD.

Q3. How does Metrics Research contribute to nephrology research in Pakistan?

Metrics Research is actively involved in and contributed to the progression of the Pakistan Renal Data System (PKRDS), a dedicated hemodialysis registry serving as a dynamic platform that collects real-world data on demographics, health status, lab parameters, and extent of complications in End-Stage Kidney Disease (ESKD) patients across the country.

Q4. How Metrics Research is involved in Pakistan Renal Data System (PKRDS)?

Metrics Research significantly contributes to the Pakistan Renal Data System (PKRDS) through nationwide data collection, ensuring comprehensive coverage of diverse populations,handling large-scale data management from multiple hemodialysis centres across Pakistan, including remote areas, and in-depth analysis of the gathered data delivers an accurate real-world database of ESKD patients undergoing hemodialysis in Pakistan.

Q5. What primary solutions were implemented to overcome the challenges in this pioneering renal registry?

Implemented strategic resource planning to allocate resources efficiently across Pakistan, targeted outreach to potential hemodialysis centers, engaged healthcare professionals, empowerment of centers through education and training & large volume data management utilizing a secure cloud-based platform for storage.

Q6. What impact has Metrics Research had on nephrology healthcare in Pakistan through its contributions to the PKRDS initiative?

This registry provides an evidence-based platform that enables informed decision-making, identifies existing challenges, and actively influences public health policies to foster better patient outcomes in Pakistan & globally.

Q7. How does Metrics Research plan to expand its contributions in the renal segment in Pakistan?

Metrics Research is focused on expanding the real-world data boundaries aligning with a new initiative of PSN to establish the Pakistan Renal Registry (PRR), which aims to comprehensively cover information from a varied spectrum of patients on treatments and underlying etiologies of kidney diseases focusing on glomerulonephritis, chronic kidney disease, End-Stage Kidney Disease (ESKD), hemodialysis, peritoneal dialysis and renal transplantation.

References:

  1. Hasan, M., Sutradhar, I., Gupta, R. D., & Sarker, M. (2018). Prevalence of chronic kidney disease in South Asia: a systematic BMC nephrology, 19, 1-12.
  2. Federation, I. D. (2021). Diabetes in Pakistan (2021). Retrieved from International Diabetes Federation: https://idf.org/our-network/regions-and-members/middle-east-and-north-africa/members/pakistan/

Trial Insurance

  • Customized coverage for clinical trial participant.
  • Risk assessment and tailored insurance solutions
  • Compliance with international and national level regulations.

IT Solutions

  • Enabling collaborations with the EDC tool vendor.
  • Providing IT-enabled data management support.
  • Integrating data from various sources to facilitate efficient data management.
  • Monitoring site performance for optimizing the use of resources.
  • Maintaining audit trails for tracking changes to ensure data integrity through EDC tools.

Specimen Shipment & Handling

  • Secure and compliant handling of biological specimens.
  • Temperature-controlled packaging and shipping.
  • Collaborative services with global logistics network for specimen transportation.
  • Ensuring regulatory compliance for international shipments.
  • Expertise in managing various specimen types, including blood, tissue, and urine.

Clinical Trial Ancillary Supplies

  • Enabling the sponsors with the ancillary supplies for clinical trials.
  • Comprehensive inventory management and tracking.
  • Customizing supply chain solutions to meet trial-specific needs.
  • Ensuring timely supply services.
  • Providing cost efficient solutions to optimize trial budgets.

IP/ Placebo / Comparator Sourcing

  • In-house services for sourcing of Investigational Products, comparators, and placebos.
  • Collaboration with suppliers and manufacturers.
  • Experienced team for procurement and logistics management.

Central Laboratory Testing

  • Collaborative services for diagnostic and clinical testing.
  • Enabling sponsors to evaluate diverse range of clinical endpoints through diagnostic tests.
  • Meeting quality standards and regional regulatory compliance.
  • Standardized procedures for authentic and credible outcomes.

Percentage Of Total Contributions

Head Office:

Karachi: Plot No. B-10, Block 16, WCHS, KDA Scheme No.24, Gulshan E Iqbal, Karachi – Pakistan.

Regional Office:

Flat No. 2, first floor, 2-C Plaza ( First floor of M.A Dental Clinic) Pakeeza Market, Sector I-8/4, Islamabad, Pakistan

Regional Presence:

  • Sindh
  • Punjab
  • Balochistan
  • Khyber Pakhtunkhwa