PBPK / PD modeling has been extensively applied: to quantitatively translate in vitro data, predict the in vivo performance, and ultimately support waivers of in vivo clinical studies.
PK Models Via PBPK
Metrics Research Offers its services of OPEN-SOURCE (PK-Sim ® & MoBI ®) software to create physiologically-based QSP platforms as Insilico Modeling & Simulation solutions to support Pharmaceuticals, Drug Discovery & Development Institutes and Regulatory Authorities for decision making process along the entire life cycle of pharmaceutical products from research to the clinical use of the product.
Member & Collaborator
We provide services for standard applications of PBPK models using the Open-Systems-Pharmacology Suite with PK-Sim ® and MoBI ®. Services are:
Determination of Pharmacokinetic Profile in Healthy & Diseased Virtual Human Population
Population Variations (American, European, Asian, Black etc.)
First in Man Dose Predictions
Preclinical/clinical base PBPK model development
Special populations: PBPK-based pediatric investigations and organ impairment studies
Metrics Research have resource experiencing PBPK in Pakistan using
Below are the projects on which we have worked till now, Published!
Enzyme and Transporter Kinetics for CPT-11 (Irinotecan) and SN-38: An Insight on Tumor Tissue Compartment Pharmacokinetics Using PBPK (view article)
Physiologically based pharmacokinetic modeling for predicting Irinotecan exposure in human body (view article)
Prediction of Clearance in Neonates and Infants (≤3 months of age) for Drugs which are Glucuronidated: A Comparative Study between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling
Prediction of Clearance and Dose of Midazolam in Preterm and Term Neonates: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling (view article)