Physiology Based PK/PD Modeling.

Novel approach for drug development

PBPK / PD modeling has been extensively applied: to quantitatively translate in vitro data, predict the in vivo performance, and ultimately support waivers of in vivo clinical studies.

PK Models Via PBPK

Metrics Research Offers its services of OPEN-SOURCE (PK-Sim ® & MoBI ®) software to create physiologically-based QSP platforms as Insilico Modeling & Simulation solutions to support Pharmaceuticals, Drug Discovery & Development Institutes and Regulatory Authorities for decision making process along the entire life cycle of pharmaceutical products from research to the clinical use of the product.

Member & Collaborator

PBPK Capability

PBPK Consulting

We provide services for standard applications of PBPK models using the Open-Systems-Pharmacology Suite with PK-Sim ® and MoBI ®.
Services are:

  • Determination of Pharmacokinetic Profile in Healthy & Diseased Virtual Human Population
  • Population Variations (American, European, Asian, Black etc.)
  • DDI Investigations
  • First in Man Dose Predictions
  • Preclinical/clinical base PBPK model development
  • Special populations: PBPK-based pediatric investigations and organ impairment studies


Metrics Research have resource experiencing PBPK in Pakistan using

Below are the projects on which we have worked till now, Published!

  1. Enzyme and Transporter Kinetics for CPT-11 (Irinotecan) and SN-38: An Insight on Tumor Tissue Compartment Pharmacokinetics Using PBPK (view article)
  2. Physiologically based pharmacokinetic modeling for predicting Irinotecan exposure in human body (view article)
  3. Prediction of Clearance in Neonates and Infants (≤3 months of age) for Drugs which are Glucuronidated: A Comparative Study between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling
    (view article)
  4. Prediction of Clearance and Dose of Midazolam in Preterm and Term Neonates: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling (view article)